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1

Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase

Mark A. Fisher, Prem N. S. Yadav, Janardan Yadav, David Kristol, Edward Arnold, Mukund J. Modak

Journal:

Journal of Molecular Recognition

Year:

1994

Language:

english

File:

PDF, 493 KB

english, 1994

2

Purification of nucleotide-linked peptide

Virendra N. Pandey, Mukund J. Modak

Journal:

Journal of Chromatography A

Year:

1988

Language:

english

File:

PDF, 494 KB

english, 1988

3

A new DNA polymerase I fromGeobacillus caldoxylosilyticusTK4: cloning, characterization, and mutational analysis of two aromatic residues

Cemal Sandalli, Kamalendra Singh, Mukund J. Modak, Amit Ketkar, Sabriye Canakci, İsmail Demir, Ali Osman Belduz

Journal:

Applied Microbiology and Biotechnology

Year:

2009

Language:

english

File:

PDF, 612 KB

english, 2009

4

Comparison of DIG-11-dUTP utilization byGeobacillus caldoxylosilyticusTK4,Mycobacterium tuberculosisandEscherichia coliDNA polymerases

Cemal Sandalli, Sabriye Canakci, İsmail Demir, Mukund J. Modak, Ali Osman Belduz

Journal:

World Journal of Microbiology and Biotechnology

Year:

2010

Language:

english

File:

PDF, 305 KB

english, 2010

5

Adenosine 5′-triphosphate (ATP)-mediated stimulation and suppression of DNA synthesis in lymphoid cells. II. Suppressive effect of ATP on murine T-cell functions

Susumu Ikehara, Robert A. Good, Mukund J. Modak, Rajendra N. Pahwa

Journal:

International Journal of Immunopharmacology

Year:

1983

Language:

english

File:

PDF, 523 KB

english, 1983

6

Valine of the YVDD Motif of Moloney Murine Leukemia Virus Reverse Transcriptase: Role in the Fidelity of DNA Synthesis†

Kaushik, Neerja, Chowdhury, Kajal, Pandey, Virendra N., Modak, Mukund J.

Journal:

Year:

2000

Language:

english

File:

PDF, 344 KB

english, 2000

7

Tyrosine 222, a Member of the YXDD Motif of MuLV RT, Is Catalytically Essential and Is a Major Component of the Fidelity Center†

Kaushik, Neerja, Singh, Kamalendra, Alluru, Indira, Modak, Mukund J.

Journal:

Year:

1999

Language:

english

File:

PDF, 201 KB

english, 1999

8

Elucidation of the Role of Arg 110 of Murine Leukemia Virus Reverse Transcriptase in the Catalytic Mechanism: Biochemical Characterization of Its Mutant Enzymes†

Chowdhury, Kajal, Kaushik, Neerja, Pandey, Virendra N., Modak, Mukund J.

Journal:

Year:

1996

Language:

english

File:

PDF, 444 KB

english, 1996

9

Role of Methionine 184 of Human Immunodeficiency Virus Type-1 Reverse Transcriptase in the Polymerase Function and Fidelity of DNA Synthesis

Pandey, Virendra N., Kaushik, Neerja, Rege, Nisha, Sarafianos, Stefanos G., Yadav, Prem N. S., Modak, Mukund J.

Journal:

Year:

1996

Language:

english

File:

PDF, 401 KB

english, 1996

10

The mechanism of inhibition of avian myeloblastosis virus reverse transcriptase by a dialdehyde derivative of ATP Inactivation of essential sulfhydryl group function

Shiv K. Srivastava, Kakkudiyil I. Abraham, Mukund J. Modak

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1983

Language:

english

File:

PDF, 571 KB

english, 1983

11

Structure-based design of inhibitors of HIV-1 reverse transcriptase: a potential class of bidentate nonnucleoside inhibitors

Prem N.S Yadav, Kalyan Das, Jianping Ding, Edward Arnold, Janardan S Yadav, Mukund J Modak

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

1998

Language:

english

File:

PDF, 363 KB

english, 1998

12

A unified DNA- and dNTP-binding mode for DNA polymerases

Kamalendra Singh, Mukund J Modak

Journal:

Trends in Biochemical Sciences

Year:

1998

Language:

english

File:

PDF, 916 KB

english, 1998

13

Site directed mutagenesis of DNA polymerase I (Klenow) from Escherichia coli : The significance of Arg682 in catalysis

Virendra N. PANDEY, Neerja KAUSHIK, Rita P. SANZGIRI, Manohar S. PATIL, Mukund J. MODAK, Sailen BARIK

Journal:

Year:

1993

Language:

english

File:

PDF, 798 KB

english, 1993

14

Template-specific requirements for DNA synthesis by the Mason-Pfizer monkey virus DNA polymerase: Unique aspects

Stuart L. Marcus, Nurul H. Sarkar, Mukund J. Modak

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1978

Language:

english

File:

PDF, 873 KB

english, 1978

15

Divalent cation-dependent pyridoxal 5′-phosphate inhibition of Rauscher leukemia virus DNA polymerase. Characterization and mechanism of action

Mukund J. Modak, U.J. Dumaswala

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1981

Language:

english

File:

PDF, 746 KB

english, 1981

16

The mechanism of inorganic phosphate-mediated inhibition of calf thymus DNA polymerase β and Rauscher leukemia virus DNA polymerase

Mukund J. Modak, Krishnamurty Rao, Stuart L. Marcus

Journal:

Biochemical and Biophysical Research Communications

Year:

1982

Language:

english

File:

PDF, 506 KB

english, 1982

17

Synthesis of compositionally unique DNA by terminal deoxynucleotidyl transferase

Mitali Basu, Mahabaleshwar V. Hegde, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1983

Language:

english

File:

PDF, 668 KB

english, 1983

18

Terminal deoxynucleotidyl transferase (TdT) enzyme in thymus and bone marrow: I. Age-associated decline of TdT in humans and mice

Rajendra N. Pahwa, Mukund J. Modak, Teresa McMorrow, Savita Pahwa, Gabriel Fernandes, Robert A. Good

Journal:

Cellular Immunology

Year:

1981

Language:

english

File:

PDF, 625 KB

english, 1981

19

Structure-activity analyses of HIV-1 reverse transcriptase

Amaresh Basu, Subhalakshmi Basu, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 596 KB

english, 1992

20

Mechanism of o-phenanthroline mediated inhibition of E. coli DNA polymerase I: Formation of template-primer-metal-phenanthroline complexes with resultant loss of catalytic activity

Kakkudiyil I. Abraham, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1983

Language:

english

File:

PDF, 566 KB

english, 1983

21

Evidence for template-specific sites in DNA polymerases

Stuart L. Marcus, Mukund J. Modak, Liebe F. Cavalieri

Journal:

Biochemical and Biophysical Research Communications

Year:

1974

Language:

english

File:

PDF, 356 KB

english, 1974

22

Pyridoxal 5′ phosphate: A selective inhibitor of oncornaviral DNA polymerases

Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 411 KB

english, 1976

23

Terminal deoxyribonucleotidyl transferase activity in acute undifferentiated leukemia

Stuart L. Marcus, Steven W. Smith, Charles I. Jarowski, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 1.45 MB

english, 1976

24

Selective inhibition of terminal deoxynucleotidyl transferase (TdT) by adenosine ribonucleoside triphosphate (ATP) and its application in the detection of TdT in human leukemia

Ravi B. Bhalla, Morton K. Schwartz, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 321 KB

english, 1977

25

DNA polymerases of human tonsil and chicken bursa: Absence of a distinct B cell specific terminal deoxynucleotidyl transferase

Mukund J. Modak, Harshida Bhatt, Scott Seidner, Edwin C. Hahn, Sudhir Gupta, Robert A. Good

Journal:

Biochemical and Biophysical Research Communications

Year:

1978

Language:

english

File:

PDF, 408 KB

english, 1978

26

Reverse transcriptase-associated RNase H. Part IV. Pyrophosphate does not inhibit RNase H activity of AMV DNA polymerase

Arun Srivastava, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 488 KB

english, 1979

27

Observations on the phosphonoformic acid inhibition of RNA dependent DNA polymerases

Mukund J. Modak, Arun Srivastava, Ellen Gillerman

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 707 KB

english, 1980

28

Purification and properties of murine mammary tumor virus DNA polymerase

Stuart L. Marcus, Nurul H. Sarkar, Mukund J. Modak

Journal:

Year:

1976

Language:

english

File:

PDF, 1.17 MB

english, 1976

29

DNA polymerase associated with nuclear membrane of calf thymus

Shonen Yoshida, Mukund J. Modak, Kunio Yagi

Journal:

Biochemical and Biophysical Research Communications

Year:

1971

Language:

english

File:

PDF, 287 KB

english, 1971

30

DNA complementary to rabbit globin mRNA made by E. coli polymerase I

Mukund J. Modak, Stuart L. Marcus, Liebe F. Cavalieri

Journal:

Biochemical and Biophysical Research Communications

Year:

1973

Language:

english

File:

PDF, 395 KB

english, 1973

31

Synthesis of DNA complementary to AMV RNA using E. coli polymerase I

Mukund J. Modak, Stuart L. Marcus, Liebe F. Cavalieri

Journal:

Biochemical and Biophysical Research Communications

Year:

1974

Language:

english

File:

PDF, 429 KB

english, 1974

32

Preparation of (125I)-dCTP and its use as a substrate for RNA- and DNA-directed DNA synthesis

Ravi B. Bhalla, Domenico Geraci, Mukund J. Modak, Wolf Prensky, Stuart L. Marcus

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 823 KB

english, 1976

33

The artifactual nature of fluoride inhibition of reverse transcriptase and associated ribonuclease H

Shiv K. Srivastava, Ellen Gillerman, Mukund J. Modak

Journal:

Biochemical and Biophysical Research Communications

Year:

1981

Language:

english

File:

PDF, 364 KB

english, 1981

34

Cellular ras Protooncogene Expression in Human Mammary Explant Cultures : A Potential Marker for Chemical Carcinogenesis

NITIN T. TELANG, AMARESH BASU, MUKUND J. MODAK, MICHAEL P. OSBORNE

Journal:

Annals of the New York Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 429 KB

english, 1990

35

Computer-Assisted Design of Antiviral Agents Directed against Human Immunodeficiency Virus Reverse Transcriptase as Their Target

JANARDAN YADAV, PREM NARAYAN YADAV, SWAMY LAXMINARAYAN, LESLIE MICHELSON, EDWARD ARNOLD, MUKUND J. MODAK

Journal:

Annals of the New York Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 771 KB

english, 1990

36

Biochemistry of terminal deoxynucleotidyltransferase: mechanism of inhibition by adenosine 5'-triphosphate

Modak, Mukund J.

Journal:

Year:

1978

Language:

english

File:

PDF, 594 KB

english, 1978

37

Evidence for Allosterism in in Vitro DNA Synthesis on RNA Templates

Liebe F. Cavalieri, Mukund J. Modak and Stuart L. Marcus

Journal:

Proceedings of the National Academy of Sciences

Year:

1974

Language:

english

File:

PDF, 811 KB

english, 1974

38

Ferrate oxidation of murine leukemia virus reverse transcriptase: identification of the template-primer binding domain

Reddy, Gurucharan, Nanduri, Venkata B., Basu, Amaresh, Modak, Mukund J.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.25 MB

english, 1991

39

Polyamide Nucleic Acid Targeted to the Primer Binding Site of the HIV-1 RNA Genome Blocks in Vitro HIV-1 Reverse Transcription †

Lee, Reaching, Kaushik, Neerja, Modak, Mukund J., Vinayak, Ravi, Pandey, Virendra N.

Journal:

Year:

1998

Language:

english

File:

PDF, 384 KB

english, 1998

40

Polyamide Nucleic Acid−DNA Chimera Lacking the Phosphate Backbone Are Novel Primers for Polymerase Reaction Catalyzed by DNA Polymerases †

Misra, Hari S., Pandey, Pradeep K., Modak, Mukund J., Vinayak, Ravi, Pandey, Virendra N.

Journal:

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

41

Terminal deoxynucleotidyltransferase containing megadalton complex from young rat thymus nuclei: identification and characterization

Pandey, V. N., Dave, V. P., Patil, M. S., Pradhan, D. S., Amrute, S. B., Modak, Mukund J.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.08 MB

english, 1990

42

Photoaffinity labeling of the primer binding domain in murine leukemia virus reverse transcriptase

Tirumalai, Radhakrishna S., Modak, Mukund J.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.91 MB

english, 1991

43

Properties of tyrosine 766 .fwdarw. serine mutant of Escherichia coli DNA polymerase I: Template-specific effects

Desai, Shyamal D., Pandey, Virendra N., Modak, Mukund J.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.75 MB

english, 1994

44

Contribution of Polar Residues of the J-Helix in the 3‘−5‘ Exonuclease Activity of Escherichia coli DNA Polymerase I (Klenow Fragment): Q677 Regulates the Removal of Terminal Mismatch †

Singh, Kamalendra, Modak, Mukund J.

Journal:

Year:

2005

Language:

english

File:

PDF, 392 KB

english, 2005

45

Role of Glutamine-151 of Human Immunodeficiency Virus Type-1 Reverse Transcriptase in RNA-Directed DNA Synthesis †

Kaushik, Neerja, Harris, Dylan, Rege, Nisha, Modak, Mukund J., Yadav, Prem N. S., Pandey, Virendra N.

Journal:

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

46

Rose Bengal mediated inhibition of DNA polymerases: mechanism of inhibition of avian myeloblastosis virus reverse transcriptase under nonoxidative conditions

Srivastava, Shiv K., Modak, Mukund J.

Journal:

Year:

1982

Language:

english

File:

PDF, 846 KB

english, 1982

47

Pyridoxal 5'-phosphate mediated inactivation of Escherichia coli DNA polymerase I: identification of lysine-635 as an essential residue for the processive mode of DNA synthesis

Basu, Subhalakshmi, Basu, Amaresh, Modak, Mukund J.

Journal:

Year:

1988

Language:

english

File:

PDF, 2.50 MB

english, 1988

48

Biochemistry of terminal deoxynucleotidyltransferase: characterization and properties of photoaffinity labeling with 8-azidoadenosine 5'-triphosphate

Abraham, Kakkudiyil I., Haley, Boyd, Modak, Mukund J.

Journal:

Year:

1983

Language:

english

File:

PDF, 2.83 MB

english, 1983

49

Significance of the O-Helix Residues of Escherichia coli DNA Polymerase I in DNA Synthesis: Dynamics of the dNTP Binding Pocket †

Kaushik, Neerja, Pandey, Virendra N., Modak, Mukund J.

Journal:

Year:

1996

Language:

english

File:

PDF, 572 KB

english, 1996

50

Identification of the primer binding domain in human immunodeficiency virus reverse transcriptase

Basu, Amaresh, Ahluwalia, Kiranjit K., Basu, Subhalakshmi, Modak, Mukund J.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.97 MB

english, 1992

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